Peppers recorded two sacks, dropping the Texans' Matt Schaub for a six-yard loss late in the first half and the Colts' Andrew Luck for a two-yard loss midway through the fourth quarter.
Jennings finished second on the NFC with four solo tackles, while Peppers and Tillman had three apiece. Melton knifed up the middle and deflected a Schaub pass.
Shortly after the game, Melton took to Twitter and wrote: "That was awesome. Everyone came out healthy and was pretty competitive till the NFC took the game over! I will be back!"
After the AFC recovered a fumble by the Vikings' Adrian Peterson on the game's first play from scrimmage, Texans defensive end J.J. Watt was inserted on offense and split out wide as a receiver.
Tillman broke up Peyton Manning's slant pass to the 6-5, 295 pound defensive lineman, but yielded a six-yard touchdown pass from Manning to the Bengals' A.J. Green on the next play.
Later in the contest, Tillman punched the ball away from Green after a reception, but the officials blew the play dead before the fumble, ruling that the receiver's forward progress had been stopped.
Tillman served as one of the NFC team captains along with Packers center Jeff Saturday and Redskins linebacker London Fletcher.
Vikings tight end Kyle Rudolph was named Pro Bowl MVP after catching five passes for 122 yards and one touchdown. The Giants' Victor Cruz had 10 receptions for 96 yards and 1 TD, while the Buccaneers' Vincent Jackson caught six passes for 91 yards and two touchdowns.
The 62 points by the NFC were the most ever by one team in the Pro Bowl, and the 97 combined points were the third most in the history of the all-star game.